Causes of psoriasis

With the modern development of medicine and a lot of research being done, scientists cannot fully determine the true causes of the development of squamous lichen. Psoriasis is a disorder of the skin and the tissues surrounding the joints. The disease is characterized by a non-infectious course, with the appearance of papules and red spots, prone to fusion. These formations are dry, scaly, rise above the surface of the skin and represent a chronic and localized process. Microscopy determines a large number of keratinocytes, cells of the immune system (T lymphocytes and macrophages), with abundant growth of the vascular network.

Psoriasis and its causes, with this development of medicine, are actively studied, but no one determines the final cause of the appearance.

Scientists identify several main bases for the development of the pathology:

  • Genetics- the hereditary theory of the appearance of psoriasis is based on the fact that if the ancestors or close relatives have this pathology, the risk of its occurrence in subsequent generationsis equal to 25% if one of the parents is ill. With the development of the disease in both parents, the risk of its occurrence in the offspring is 70%. One possible option is when a healthy child is born to sick parents, but after some time, under the influence of the above factors, the disease develops in him.
  • Immune Defect- By examining the histological material of patients with psoriasis, scientists have revealed an excessive buildup of diseased immune cells in the layers of the epidermis. At the same time, specific antibodies were found, and in the upper layers of the epidermis - Munro microabscess (accumulation of intercellular fluid, leukocytes, macrophages). A general blood test shows an increase in the number of leukocytes (T-helpers), all of this speaks to the autoimmune nature of the disease.
  • Viral injury- in this case it means infection with retroviruses. This strain inserts its own chain of tRNA into the host cell, replacing its genetic code with a viral code. This is manifested by an excessive production and multiplication of immature and undifferentiated dermal cells.

An interesting fact is that anti-psoriatic therapy according to autoimmune theory aims to reduce the number of immune cells, including T-helpers. In the presence of psoriasis in people infected with HIV / AIDS, the number of these cells decreases to the limit values ​​and the risk of developing psoriasis increases. Further investigation of this fact may completely refute the autoimmune theory of the development of psoriasis.

Factors in the development of psoriasis

causes of psoriasis

What are the causes of psoriasis? There are several provoking factors that negatively affect the body:

  • Stress- this factor is the trigger of the psoriatic rash and the last link, under the influence of which the rash is reduced. This factor is one of the main ones, because the onset of psoriasis in 50% of cases occurs precisely due to extreme fatigue, psychological trauma and nervous tension. With the onset of remission of psoriasis, any mental shock can cause a relapse;
  • Infections- a group of diseases, with the development of which primary foci of psoriatic rash have appeared. These diseases include: all infectious diseases of the upper respiratory tract, bacterial and fungal infections affecting the skin, mononucleosis. In patients with psoriasis, the presence of an increased amount of pathogenic microflora (beta-hemolytic streptococcus and Staphylococcus aureus) was determined. Candidiasis is a fungal infectious process in which psoriasis most often develops;
  • External influence- quite a number of patients associate the onset of psoriasis with external physical factors. Most often these are: mechanical trauma to the skin, burns, hypothermia and frostbite;
  • Endocrinopathies- this group of diseases is accompanied by impaired functioning of the organism as a whole. This factor is found most often in the female sex, due to frequent changes in hormonal levels related to growth, pregnancy, menstrual cycle, menopause. In patients with diabetes mellitus, the metabolism is significantly disturbed, while a constant excess of glucose negatively affects human tissues and organs, causing the development of other diseases;
  • Toxins- act as another cause of psoriasis on the body. Its appearance is associated with food poisoning, factory or factory work, the abuse of certain products (citrus fruits, coffee, chocolate). Alcohol and smoking, with their toxic effects, cause many diseases, including psoriasis;
  • Pathogenic effect includes taking medication.It has been proven that a small number of patients have started to develop psoriasis while taking the following drugs: NSAIDs, beta-blockers, fortified drugs (vitamins C, B, D), cytostatics, antibiotics (cephalosporins).

Prevention of psoriasis

There are many factors that contribute to the development of psoriasis. The basic theory has not yet been determined and any preventive measure must be comprehensive and exhaustively targeted. Patients need to reconsider their lifestyle. If necessary, change your place of residence to a more environmentally friendly area.

It is recommended to avoid stressful situations. It is possible to take antidepressants and sedatives. The diet should include more fiber, non-allergenic fruits and vegetables, meat, fish. When treating concomitant pathologies, it is imperative to quit bad habits, to consult a doctor to replace the treatment. Take courses of treatment in specialized sanatoriums.